Publikationen
Neueste Fortschritte in der kardiovaskulären und RNA-Forschung
Entdecken Sie unsere Beiträge zum Verständnis von Herz-Kreislauf-Erkrankungen durch die Linse der RNA-Biologie. Diese vorgestellten Studien zeigen aktuelle Fortschritte aus dem Boeckel Lab und beleuchten molekulare Mechanismen, translationale Prozesse sowie neue therapeutische Ansätze.
Aktuelle Highlights
Circulation Research
2025: Kneuer et al., Analyse zirkulierender Immunzell-Signaturen bei HFpEF über Arten hinweg
European Heart Journal
2025: Boeckel & Xiao, Extrazelluläre Vesikel zur Durchführung von RNA-Therapien
Alle Publikationen ansehen
Für einen vollständigen Überblick über unsere wissenschaftliche Arbeit finden Sie unten die gesamte Liste unserer Publikationen. Diese Arbeiten spiegeln das kontinuierliche Engagement des Labs wider, die Herz-Kreislauf-Forschung durch interdisziplinäre Zusammenarbeit und RNA-basierte Erkenntnisse voranzutreiben.
| Year | Reference | DOI |
|---|---|---|
| 2025 | Kneuer JM, Müller M, Erbe S, Kokot KE, Rosch S, Müller-Kozarez I, Schröder SC, Maeder C, Heitkamp SF, Gaul S, von Haehling S, Tönjes A, Blüher M, Lurz P, Wachter R, Klinke A, Laufs U, Boeckel JN (2025). Circulating Immune Cell Signature Analysis in HFpEF Across Species. Circ Res, 137(5), 682-698. | 10.1161/CIRCRESAHA.125.326249 |
| Boeckel JN, Xiao J (2025). Extracellular vesicles to mediate RNA therapies. Eur Heart J, 46(17), 1677-1679. | 10.1093/eurheartj/ehaf046 | |
| 2024 | Stürzebecher PE, Gouni-Berthold I, Mateev C, Frenzel O, Erbe S, Boeckel JN, Scholz M, Schatz U, Weingärtner O, Kassner U, Laufs U (2024). Quality of life in patients with statin intolerance: a multicentre prospective registry study. Lancet Reg Health Eur, 43, 100981 | 10.1016/j.lanepe.2024.100981 |
| Kogel A, Baumann L, Maeder C, Büttner P, Thiele H, Kneuer JM, Boeckel JN, Laufs U, Gaul S (2024). NLRP3 inflammasome-induced pyroptosis and serum ASC specks are increased in patients with cardiogenic shock. Am J Physiol Heart Circ Physiol, 327(4), H869-H879. | 10.1152/ajpheart.00231.2024 | |
| Kneuer JM, Grajek IA, Winkler M, Erbe S, Meinecke T, Weiss R, Garfias-Veitl T, Sheikh BN, König AC, Möbius-Winkler MN, Kogel A, Kresoja KP, Rosch S, Kokot KE, Filipova V, Gaul S, Thiele H, Lurz P, von Haehling S, Speer T, Laufs U, Boeckel JN (2024). Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing. Circulation, 150(14), 1101-1120. | 10.1161/CIRCULATIONAHA.124.069315 | |
| 2023 | Maeder C, Speer T, Wirth A, Boeckel JN, Fatima S, Shahzad K, Freichel M, Laufs U, Gaul S (2023). Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis. Front Immunol, 14, 1252384. | 10.3389/fimmu.2023.1252384 |
| Henschke V, Hild K, Schilling E, Haas J, Filipova V, Erbe S, König R, Hübschen JM, Laufs U, Claus C, Boeckel JN (2023). Rubella virus infection in endothelial cells reduces angiogenesis via interferon beta-induced CXCL10. iScience, 26(4), 106352. | 10.1016/j.isci.2023.10635210.1016/j.isci.2023.106352 | |
| Zhou Q, Boeckel JN, Yao J, Zhao J, Bai Y, Lv Y, Hu M, Meng D, Xie Y, Yu P, Xi P, Xu J, Zhang Y, Dimmeler S, Xiao J (2023). Diagnosis of acute myocardial infarction using a combination of circulating circular RNA cZNF292 and clinical information based on machine learning. MedComm, 4(3), e299. | 10.1002/mco2.299 | |
| 2022 | Bondareva O, Rodríguez-Aguilera JR, Oliveira F, Liao L, Rose A, Gupta A, Singh K, Geier F, Schuster J, Boeckel JN, Buescher JM, Kohli S, Klöting N, Isermann B, Blüher M, Sheikh BN (2022). Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity. Nat Metab, 4(11), 1591-1610. | 10.1038/s42255-022-00674-x |
| Müller M, Eghbalian R, Boeckel JN, Frese KS, Haas J, Kayvanpour E, Sedaghat-Hamedani F, Lackner MK, Tugrul OF, Ruppert T, Tappu R, Martins Bordalo D, Kneuer JM, Piekarek A, Herch S, Schudy S, Keller A, Grammes N, Bischof C, Klinke A, Cardoso-Moreira M, Kaessmann H, Katus HA, Frey N, Steinmetz LM, Meder B (2022). NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Nat Commun, 13(1), 6209. | 10.1038/s41467-022-33658-2 | |
| Stürzebecher PE, Kralisch S, Schubert MR, Filipova V, Hoffmann A, Oliveira F, Sheikh BN, Blüher M, Kogel A, Scholz M, Kokot KE, Erbe S, Kneuer JM, Ebert T, Fasshauer M, Miehle K, Laufs U, Tönjes A, Boeckel JN (2022). Leptin treatment has vasculo-protective effects in lipodystrophic mice. Proc Natl Acad Sci U S A, 119(40), e2110374119. | 10.1073/pnas.2110374119 | |
| Kayvanpour E, Wisdom M, Lackner MK, Sedaghat-Hamedani F, Boeckel JN, Müller M, Eghbalian R, Dudek J, Doroudgar S, Maack C, Frey N, Meder B (2022). VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation. Int J Mol Sci, 23(13), 7327. | 10.3390/ijms23137327 | |
| Gaul S, Shahzad K, Medert R, Gadi I, Mäder C, Schumacher D, Wirth A, Ambreen S, Fatima S, Boeckel JN, Khawaja H, Haas J, Brune M, Nawroth PP, Isermann B, Laufs U, Freichel M (2022). Novel Nongenetic Murine Model of Hyperglycemia and Hyperlipidemia-Associated Aggravated Atherosclerosis. Front Cardiovasc Med, 9, 813215. | 10.3389/fcvm.2022.813215 | |
| Kokot KE, Kneuer JM, John D, Rebs S, Möbius-Winkler MN, Erbe S, Müller M, Andritschke M, Gaul S, Sheikh BN, Haas J, Thiele H, Müller OJ, Hille S, Leuschner F, Dimmeler S, Streckfuss-Bömeke K, Meder B, Laufs U, Boeckel JN (2022). Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs. Basic Res Cardiol, 117(1), 32. | 10.1007/s00395-022-00940-9 | |
| Boeckel JN, Möbius-Winkler M, Müller M, Rebs S, Eger N, Schoppe L, Tappu R, Kokot KE, Kneuer JM, Gaul S, Bordalo DM, Lai A, Haas J, Ghanbari M, Drewe-Boss P, Liss M, Katus HA, Ohler U, Gotthardt M, Laufs U, Streckfuss-Bömeke K, Meder B (2022). SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy. Genomics Proteomics Bioinformatics, 20(1), 129-146. | 10.1016/j.gpb.2021.01.006 | |
| 2021 | Gaul S, Schaeffer KM, Opitz L, Maeder C, Kogel A, Uhlmann L, Kalwa H, Wagner U, Haas J, Behzadi A, Pelegrin P, Boeckel JN, Laufs U (2021). Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells and induce pro-atherogenic effects. Sci Rep, 11(1), 15156. | 10.1038/s41598-021-94314-1 |
| 2020 | Glaser SF, Heumüller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Günther S, Kokot KE, Hassel D, Kumar S, Jo H, Boon RA, Abplanalp W, John D, Boeckel JN, Dimmeler S (2020). The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. Proc Natl Acad Sci U S A, 117(8), 4180-4187. | 10.1073/pnas.1913481117 |
| Zehendner CM, Valasarajan C, Werner A, Boeckel JN, Bischoff FC, John D, Weirick T, Glaser SF, Rossbach O, Jaé N, Demolli S, Khassafi F, Yuan K, de Jesus Perez VA, Michalik KM, Chen W, Seeger W, Guenther A, Wasnick RM, Uchida S, Zeiher AM, Dimmeler S, Pullamsetti SS (2020). Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFRβ. Am J Respir Crit Care Med, 202(10), 1445-1457. | 10.1164/rccm.201910-2041OC | |
| Glaser SF, Heumüller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Günther S, Kokot KE, Hassel D, Kumar S, Jo H, Boon RA, Abplanalp W, John D, Boeckel JN, Dimmeler S (2020). The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. Proc Natl Acad Sci U S A, 117(8), 4180-4187. | 10.1073/pnas.1913481117 | |
| 2019 | Schuster S, Rubil S, Endres M, Princen HMG, Boeckel JN, Winter K, Werner C, Laufs U (2019). Anti-PCSK9 antibodies inhibit pro-atherogenic mechanisms in APOE*3Leiden. CETP mice. Sci Rep, 9(1), 11079. | 10.1038/s41598-019-47242-0 |
| Boeckel JN, Perret MF, Glaser SF, Seeger T, Heumuller AW, Chen W, John D, Kokot KE, Katus HA, Haas J, Lackner MK, Kayvanpour E, Grabe N, Dieterich C, von Haehling S, Ebner N, Hunecke S, Leuschner F, Fichtlscherer S, Meder B, Zeiher AM, Dimmeler S, Keller T (2019). Identification and regulation of the long non-coding RNA Heat2 in heart failure. J Mol Cell Cardiol, 126, 13-22. | 10.1016/j.yjmcc.2018.11.004 | |
| 2018 | Heumuller AW, Boeckel JN (2018). Characterization and Validation of Circular RNA and Their Host Gene mRNA Expression Using PCR. Methods Mol Biol, 1724, 57-67. | 10.1007/978-1-4939-7562-4_5 |
| Eger N, Schoppe L, Schuster S, Laufs U, Boeckel JN (2018). Circular RNA Splicing. Adv Exp Med Biol, 1087, 41-52. | 10.1007/978-981-13-1426-1_4 | |
| Haas J, Mester S, Lai A, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Rausch T, Nietsch R, Boeckel JN, Carstensen A, Volkers M, Dietrich C, Pils D, Amr A, Holzer DB, Martins Bordalo D, Oehler D, Weis (2018). Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy. EMBO Mol Med, 10(1), 107-120. | 10.15252/emmm.201707838 | |
| Boeckel JN, Palapies L, Klotsche J, Zeller T, von Jeinsen B, Perret MF, Kleinhaus SL, Pieper L, Tzikas S, Leistner D, Bickel C, Stalla GK, Lehnert H, Lindahl B, Wittchen HU, Silber S, Baldus S, Maerz W, Dimmeler S, Blankenberg S, Münzel T, Zeiher AM, Keller T (2018). Adjusted Troponin I for Improved Evaluation of Patients with Chest Pain. Sci Rep, 8(1), 8087. | 10.1038/s41598-018-26120-1 | |
| 2017 | Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C (2017). Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. J Mol Cell Cardiol, 109, 48-56. | 10.1016/j.yjmcc.2017.06.015 |
| Bischoff FC, Werner A, John D, Boeckel JN, Melissari MT, Grote P, Glaser SF, Demolli S, Uchida S, Michalik KM, Meder B, Katus HA, Haas J, Chen W, Pullamsetti SS, Seeger W, Zeiher AM, Dimmeler S, Zehendner CM (2017). Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes. Circ Res, 121(4), 368-375. | 10.1161/CIRCRESAHA.116.310531 | |
| De Rosa R, Vasa-Nicotera M, Leistner DM, Reis SM, Thome CE, Boeckel JN, Fichtlscherer S, Zeiher AM (2017). Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors - Insights From an Optical Coherence Tomography Study. Circ J, 81(8), 1165-1173. | 10.1253/circj.CJ-17-0054 | |
| Keller T, Boeckel JN, Groß S, Klotsche J, Palapies L, Leistner D, Pieper L, Stalla GK, Lehnert H, Silber S, Pittrow D, Maerz W, Dörr M, Wittchen HU, Baumeister SE, Völker U, Felix SB, Dimmeler S, Zeiher AM (2017). Improved risk stratification in prevention by use of a panel of selected circulating microRNAs. Sci Rep, 7(1), 4511. | 10.1038/s41598-017-04040-w | |
| De Rosa R, De Rosa S, Leistner D, Boeckel JN, Keller T, Fichtlscherer S, Dimmeler S, Zeiher AM (2017). Transcoronary Concentration Gradient of microRNA-133a and Outcome in Patients With Coronary Artery Disease. Am J Cardiol, 120(1), 15-24. | 10.1016/j.amjcard.2017.03.264 | |
| 2016 | Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S (2016). Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med, 22(10), 1140-1150. | 10.1038/nm.4172 |
| Leistner DM, Boeckel JN, Reis SM, Thome CE, De Rosa R, Keller T, Palapies L, Fichtlscherer S, Dimmeler S, Zeiher AM (2016). Transcoronary gradients of vascular miRNAs and coronary atherosclerotic plaque characteristics. Eur Heart J, 37(22), 1738-49. | 10.1093/eurheartj/ehw047 | |
| Boeckel JN, Derlet A, Glaser SF, Luczak A, Lucas T, Heumüller AW, Krüger M, Zehendner CM, Kaluza D, Doddaballapur A, Ohtani K, Treguer K, Dimmeler S (2016). JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells. Arterioscler Thromb Vasc Biol, 36(7), 1425-33. | 10.1161/ATVBAHA.116.307695 | |
| Boeckel JN, Oppermann J, Anadol R, Fichtlscherer S, Zeiher AM, Keller T (2016). Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model. Sci Rep, 6, 20812. | 10.1038/srep20812 | |
| Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S (2015). Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA. Circ Res, 117(10), 884-90. | 10.1161/CIRCRESAHA.115.306319 |